The Suspending Properties of Cissus Rubiginosa Fruit Mucilage in Paracetamol Suspension Formulation
Date
2017
Authors
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Journal ISSN
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Publisher
Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria
Abstract
Introduction; Materials and Methods; Results and Discussions; References.
Description
Suspensions are defined as heterogeneous systems consisting of two phases. The continuous or external phase is usually liquid or semisolid while the dispersed phase or internal phase is almost always an insoluble solid (Singh et al., 2013). A pharmaceutical suspension, like any other disperse system is thermodynamically unstable, thus making it necessary to include a stabilizer or suspending agent.
Materials with suspending properties like mucilage have been obtained from natural sources and used to stabilize liquid formulations containing poorly dispersible solids. The study was to evaluated the suspending properties of Cissus rubiginosa fruit mucilage (CRM) in paracetamol oral suspension. The study has shown that Cissus rubiginosa fruit mucilage has the ability to form suspensions. Hence, the incorporation of Cissus rubiginosa fruit mucilage at 0.5 % concentration can be exploited as an alternative suspending agent in formulation of pharmaceutical oral suspensions containing insoluble solids